Since the defeat of the Green Goblin all has been quiet in New York. Peter feels he can finally take it easy with Norman Osborn behind bars and Oscorp out of business for good. Peter and Mary Jane are set to welcome their first child and Miles has been enjoying his first year in college. A coordinated attack is soon launched on Ravencroft causing Peter and Miles to leap into action. As they try to contain the situation, Peter soon realizes that this wasn't random as The Raft comes under attack moments later. The two Spidermen race to the scene to discover some of their worst enemies have been set free, now called The Sinister Six are united with a shared purpose.... destroy New York and Spiderman. Peter and Miles are outmatched as they are left severely beaten by the villains and given an ominous warning by the Green Goblin to stay out of their way. As The Sinister 6 wreak havoc on the city, Peter calls upon friends and allies to aide him in ending the villains reign of terror once and for all.
