Peter Parker is going through a difficult time, having recently lost the woman he loved, he begins to distance himself from those he knows and becomes more violent. At the Kingpin's initiative, a team of some of his worst enemies is formed in order to take advantage of his weakness to kill him for good : The Sinister Six ! However, between the Green Goblin and Doctor Octopus, who is vying for command, things are not the easiest. In addition, Parker comes into contact with a strange extraterrestrial substance having attached itself to a shuttle returning from space, which makes him a new suit, more powerful, efficient, but also seems to make him even colder and exploits his anger. Parker will learn that sometimes, even when faced with many enemies, the first one to defeat is the one who lodges in his own head...
