After the battle against the sinister six and the death of Norman Osborn, the Green Goblin, Peter Parker and Gwen Stacy are busy with college, while Peter has to continue his heroic duties, now accompanied by young Miles Morales, take pictures for the Daily Bugle and help his teacher Curtis Connors on a project involving genetic crosses between species. But when Connors' experiments go awry, Peter will have to stop him before it's too late!
