Peter Parker and Aunt May along with Mary Jane and Happy Hogan decide to take a vacation to Europe for a week to help his grandma Roberta move into a nursing home. MIT already knows about the circumstances. The vacation takes an unexpected turn when Nick Fury shows up in his hotel room to recruit him for a mission. The world is in danger as four massive elemental villains-- Sandman, Cyclone, Hydro Man and Molten Man -- emerge from a hole torn in the universe. Parker soon finds himself donning the Spider-Man suit to help Fury and fellow superhero Mysterio stop the evil entities from wreaking havoc across the continent. Little does Peter know, Mysterio is only pretending to be a hero.