Peter Parker is a prodigal student in Empire State University, New York. However 3 years ago, on field trip to Osborn Industries, he was bitten by a radioactive mutant spider which imbued him with the proportionate powers of a spider, superhuman strength, speed, agility and stamina and the ability to stick to and crawl surfaces. He adopted the mantle of Spider-man to fight crime in New York, honoring the promise he made with his paternal uncle and surrogate father, Benjamin Parker.
Peter Parker, now working as a web designer at Daily Bugle, faces off against a villain who does crimes by impersonating others, stealing valuable information and tech. Dubbed by the news as Chameleon, Spider-man fights him and beats him in public. But after his escape, he uses the identity of Spider-man to commit crimes, tarnishing Spidey's already mixed reputation as a dangerous vigilante. Spider-man has to work to capture and foil Chameleon's big plans, while clearing his name and evading pursuit by law enforcement.