In the story, Superman and Spider-Man must stop a world domination / destruction plot hatched in tandem by their respective arch-nemeses, Lex Luthor and Doctor Octopus. The issue is non-canon, as it assumes that the heroes and their respective cities of residence, Metropolis and New York City, exist in the same universe, with no explanation given as to why they had never before met or been mentioned in each other's individual stories.
