Due to the reality-changing events of Flashpoint, the members of the Super-Family had their memories altered and their history re-written so that they forgot about their bonds. Although Superman, Supergirl, Superboy and other team members have worked together since, their relationship became more strained and distant for a while until it was restored: Superman and Supergirl patched things up after her Red Lantern stint, and Supergirl defended Superboy from her own teammates, apologising for mistreating him in the past.
In Superman: The Final Days of Superman, Prime-Earth Superman faced his own mortality and saw that Supergirl was ready to replace him.
After the events of "Superman: Reborn", Superman was made aware that reality had been tampered with by someone massively powerful and he needed the whole Super-Family to fight him, so he visited each member - Supergirl, Steel, Super-Man, and Superwoman and asked them to fight at his side when the time comes.
In Superman: Revenge the Super-Family had their first test when a new Superman Revenge Squad was put together by Cyborg Superman to destroy Superman once and for all.
