The story follows a melancholy and directionless Kara Zor-El (Supergirl) as she celebrates her 21st birthday. She encounters a young alien girl named Ruthye Marye Knoll, whose world was destroyed and who is seeking vengeance for her father's murder. Kara, Krypto the Superdog, and Ruthye embark on a journey across the cosmos to find the killer, Krem of the Yellow Hills. The narrative explores themes of trauma, revenge, and what it means to be a hero when one has lost everything.