Years after finding a home on Earth, Kara Zor-El has become a confident but emotionally guarded protector of the galaxy. When a secret Kryptonian science cult uncovers a living fragment of Krypton's lost Worldkiller program, Kara is forced to confront painful truths about her family's legacy, the survivor's guilt she has buried, and what it truly means to define herself beyond the symbol of the House of El. As worlds begin falling under the Worldkiller's control, Supergirl must become the hero the universe needs—not as Superman's cousin, but as Krypton's greatest champion.