After all the chaos that has happened in the past year, Mario and Peach decide that they need a vacation, so they pack their bags and head to Isle Delfino for what they hope to be a peaceful tropical getaway. But when they arrive to the Island they find that the entire place has been covered in strange goo, for which Mario is blamed for due to someone resembling him being spotted. Now along with F.L.U.D.D, Mario must clean up this goop and find out the true culprit along the way.
