In this live-action adaptation of the franchise as a four-quadrant five-act war drama fantasy action-adventure alternate history feminist epic, the Second Neuroi War is underway and two girls in a post-high school slump get marching orders to fight the Neuroi with the elite war witches. The girls Shizuka Hattori and Tomoko Anabuki are lucky to train in fighting Neuroi alongside the Strike Witches alias the 501st Joint Fighter Wing stationed in Britannia. The 501st is soon comprised of them and the veterans Yoshika, Lynette, Perrine, Shirley, Francesca, Mio, Eila, Sanya, Erica, Gertrud and Minna. Together, they train in using Striker Units to fly and battle the mechanical alien invaders known as the Neuroi even as they help train the world's armed forces to be ready to fight against forces of tyranny brewing under their noses. Disaster roils the Strike Witches when their Britannian gloryhound RAF commanding officer commits suicide after he fails to sabotage and abolish them. Now, the time for the Witches to really prove their worth and earn their wings comes when the RAF officer's pet project for reverse engineering one of the Neuroi goes rogue and threatens the Dover Strait towns forcing them into a major battle.
