A university professor named Dr. Robert Bolton and his partner Dr. Luther Paradgim create a machine known as the “gene-slammer” which is capable of changing aquatic animals into anthropomorphic hybrids combining their DNA. In his event Paradigm Bolton’s Four Sons John, Bobby, Coop, and Clint the likeness of four different sharks. When Dr Paradigm captures their friend Bends, the resulting “Street Sharks” rescue him and the resulting battle causes Paradigm to be combined with Pihrana DNA (for which he is nicknamed Dr Pihranoid by other characters). In subsequent episodes, Dr Paradigm creates a variety of mutant animals to destroy the Street Sharks while attempting to persuade the inhabitants of their native metropolis of Fission City to imprison them. Of these mutant animals, a few sided with the Sharks themselves: namely Rox, Moby Lick, Mantanaman, and El Swordo.
