In 2061 San Francisco, a cybernetic operative known only as the Major—a full-body cyborg with a human brain—hunts the hacker who murdered her surrogate father, Megatech founder William Skinner. Teaming with her partially cybernetic partner Batou, she discovers the killer was a shell operator identical to herself, remotely controlled by Skinner’s sociopathic son Jacob. As Jacob seizes control of Megatech and begins erasing the Major’s memories, she must ally with the very cyber-terrorist she was sent to stop—a dying hacker called the Orchestrator—to recover her past, save her partner from a fatal illness, and expose a corporate cover-up that could end cyberization forever.