When an anxious but intelligent Filipino-American high school student fifteen-year-old Marty Aquino, has always struggled to fit in. During a school visit to Oscorp Industries, he's bitten by a genetically altered spider, granting him extraordinary powers unlike anything the world has ever seen. As Marty experiments with his incredible new abilities, he initially uses them for fun and personal gain. But after a devastating family tragedy changes his life forever, he realizes that power alone means nothing without responsibility. Meanwhile, brilliant Oscorp scientist Dr. Olivia Octavius is publicly humiliated after CEO Harry Osborn claims credit for her revolutionary research before firing her. Determined to prove her genius, Olivia secretly rebuilds her experimental mechanical arms, transforming herself into the dangerous Doctor Octopus. With New York threatened by Doc Ock's relentless pursuit of revenge and the criminal rise of the sand-powered Boyd Baker alongside the mysterious Jack O'Lantern, Marty must embrace his destiny as the city's first true superhero: Spider-Man.