After being able to prove his innocence, Peter Parker (Tom Holland), finds himself in trouble now that his life as a hero is mixing with his personal life, at the same time (even innocent) a large part of the people of New York do not trust his hero, now with his responsibility doubled due to his identity exposed to everyone and all the mistrust and fear on the part of the people, Peter finds himself increasingly pressured and not knowing what to do.
In the meantime, it all turns upside down when new villains start to appear and the Doctor Strange (Benedict Cumberbach) appears in the life of the Neighborhood Buddy asking for his help. Now, Peter will have to team up with two other Spider-Men from different universes to solve a multiverse problem, while learning something from his more experienced versions.
