When a mysterious force begins erasing people from the future, Madame Web unites three extraordinary young women, Anya Corazon, Julia Carpenter and Mattie Franklin, to prevent a catastrophic collapse of reality. Haunted by visions of timelines that should never exist, the Spider Women must master their unique powers and confront a hidden enemy manipulating the threads of destiny. As their visions reveal that one of them may be responsible for the coming apocalypse, the team must learn to trust one another before the future disappears forever.