Jessica Drew obtained her powers while still in the womb when her mother got hit with a beam of DNA that contained various species of spiders. Many years later, her parents disappear and she is adopted by the leader of terrorist group HYDRA and becomes a living weapon and is trained by mercenary Deathstroke. During her first and only mission for Hydra, she is sent to assassinate Nick Fury, but during this mission, she realizes what she’s doing isn’t right and turns on HYDRA. As a result, Madame Hydra and the recently returning Red Skull send Deathstroke and a new team called the Lethal Legion to beat her. Now being allied by SHIELD, Spider-Woman fights for her own free will.