High-school senior Petra Parker, a school outcast, lives with her uncle Marc and her aunt Benita. On a school field trip, she visits a genetics laboratory with her friend Harriet Osborn and her love interest Marius John Watson. Petra is bitten by a genetically engineered "super spider". After arriving home, she becomes unconscious. Meanwhile, Harriet's mother, scientist Nora Osborn, a billionaire and the owner of Oscorp, is trying to win an important military contract. She experiments on herself with an unstable performance-enhancing chemical. After applying the chemical, she goes insane and kills her assistant, Dr. Stromm.
