After the events of Spider-Man: No Way Home, Peter Parker/Spider-Man graduated and entered college, it's seen that the hero is more experienced and mature than before. Then the Lizard appears, in which he is on a murder spree before Spider-Man tries to stop him. The Lizard poisons Spider-Man and throws him out of a building. It is later revealed that Calypso is hypnotizing the Lizard to place his order. Spider-Man defeats Calypso and the Lizard, but Spider-Man believes that the Lizard died due to Calypso's effect on his brain.
The film story is inspired by the comic book arc "Torment" by Todd McFarlane
