Peter Parker is having a normal day, reeling from Mary Jane dumping him because she could not stand Spidey saving her all the time, feeling dejected, he finds a roof to feel mopey on, but then, something happens as the night draws forth, Mysterio lurks around the halls of the Museum of Natural History, and with him is Egghead. They plan on stealing this artifact called the Unifraggond Orb, a powerful artifact said to hold the key to multiple universes. Peter gets into his Spider-Man costume and fights them off, but is then met by one of the Avengers, Janet Van Dyne/The Wasp. The two of them stall the villains, but they escape.
After seeing this, Justin Anderson/The Beyonder shows up and tells Spidey and Wasp about the situation. The fragments of the Orb are scattered across multiple realities, one in the 30's, but is not like ours, a present day out of sync, and two distant future times that may or may not happen. So, now they must work together to stop Mysterio and Egghead before the other fragments of the Unifraggond Orb fall into the wrong hands. To do this they will have to unite with the 1610 universe counterparts of them, Miguel O'Hara/Spider-Man 2099, Monique Fenton-Gomez/Wasp 2099, Spider-Man Noir, Wasp Nori and two new heroes, Spider-Man and The Wasp of the year 3000. But there is something about Wasp 3000 that she might be hiding from Beyonder. What is it? And can they stop Egghead and Mysterio before all is lost? And will it work out between Peter and Janet?
