After two years of trials, and after the beating he recieved from Peter Parker, Ben Parker's killer, a man called Cletus Kasady, has finnally been found, submited to judgement and found guilty for his murder. This means a great improvement in Peter's life, who has finished college and is working as a photographer at the Daily Bugle, and now is in a relationship with his former classmate, Gwen Stacy. Meanwhile, Norman Osborn, Harry Osborn (Peter's best friend)'s dad, is in a race against time, because he's been working on a biologic weapon project, and he has to deliever it to the government within two weeks, before his company, Oscorp, goes broke. Desperate times require desperate decisions, so Osborn decides to blackmail the warden of the prison in which Cletus is going to be executed, and manages to get him out of there, just to use him as a test subject for his experiment. The experiment goes terribly wrong, and the killer ends crazier than he originally was. With no other choice left, Norman decides to use the serum on himself, giving birth to a creature who's no longer a human being, but a hungry of destruction and chaos monster.
