The episode opens in an alternate reality as and alternate version of Spider-Man called Noir and a spider version of Gwen Stacy enter a huge warehouse where they talk to an alternate version of Adrian Toomes who in this universe is the Kingpin. Gwen tells Adrian they don't want to hurt him but they will if he doesn't give them the location of the collider. Adrian tells them that things are about to change and the multiverse will soon be under his and the rest of the Sinister Six's control. You see in the multiverse there are several spider people and some of them can interact with and cross over to the other universes. Gwen and Noir are here in this universe because alternate versions of six villains have now found a way to work together and create a collider that will give them full control of the multiverse. Gwen attacks Adrian but he flies away leaving Gwen and Noir in a crumbling universe. Meanwhile we see the Ultimate Spider-Man, Spectacular Spider-Man, and Amazing Spider-Man all trying to fight off the Iron-Rhino, Earth 1910 Doc Ock, and Electro 2099 while Adrian, Norman Parker, and Mac Gargan activate the collider. The multiverse starts to rearrange itself while the six manage to kill the three Spider-Men. Norman asks what they're going to do and Adrian tells them it is time.
