Vastly different retelling in some instances, whilst similar in other.
- Tobey's Spider-Man turns up to help fight Doc Ock on the freeway, where Strange imprisons him, fearing his presence is doing damage on the multiverse.
- Andrew's Spider-Man turns up as he does in the movie.
- A variant of villains have been put together to kill Spider-Man: Kraven, Scorpion, The Vulture, and Electro.
- Green Goblin kills Aunt May as in the film, and puts Happy in intensive care.
- War Machine, the new Captain America, and Scarlet Witch arrive to arrest the kill squad at the end of the movie.
- Tobey's Spider-Man fights Goblin, only to be severely wounded, when Tom's Spider-Man saves him, leading to the end of the movie.