Brooklyn teenager, Miles Morales, is bitten by a radioactive spider and develops the powers of Spider-Man. He comes from a family that is made up of his nurse mom, Rio Morales, police officer dad, Jefferson Davis, and his uncle who is secretly Prowler, Aaron Davis. Jefferson Davis is very vocal about being anti-Spider-Man. On top of this, Aaron Davis works for the crime boss, Wilson Fisk aka Kingpin, and is after Miles.