Peter Parker's wife, Mary Jane Watson-Parker, is pregnant and is about to give birth to their baby. Mary Jane believes her husband should consider retiring from Spider-Man and pass the mantle to his best friend & partner, Miles Morales. Things become hard when Eddie Brock reunites with the symbiote to become Venom once more. Cletus Kasady, a serial killer once put away in jail by Spider-Man in the past, is bonded with another symbiote and becomes the psychotic killer Carnage. They team up with Baron Mordo to bring Dormammu to Earth. Spider-Man & Kid Arachnid must protect Mary Jane from the symbiotes as Venom still remembers Peter Parker is Spider-Man. They team up with Iron Man, War Machine, Dr. Strange, Wong, & Clea to keep Dormammu from coming to Earth. They also have to deal with a woman who is targeting Venom & Carnage and plans to kill them by any means necessary. But Venom seems to have changed and might not be as evil as before. Carnage has no intention of helping Mordo, but to become more powerful. (Based on "Maximum Carnage" and Spider-Man: The Animated Series Season 3 Episodes 10 & 11)
