Peter Parker, aka Spider-Man, finds himself entangled in a dangerous gang war that threatens to tear New York apart. Tombstone, Silvermane, Hammerhead, Scorpion and Mr. Negative vie for control, creating chaos in the city's underworld. Unbeknownst to Spider-Man, the elusive Chameleon (who was hired by Norman Osborn) is orchestrating the conflict from the shadows. As Spidey navigates the treacherous web of deceit, he discovers a teenager, Miles Morales, who has been bitten by radioactive spider.
