As Peter Parker prepares for his high school orientation, his life takes an unexpected turn when he gains spider-like abilities. In this alternate universe, a temporal paradox involving Doctor Strange and a symbiotic alien leads to Peter being bitten by a spider infused with his own blood, granting him unique powers. With Norman Osborn stepping in as his mentor, Peter navigates the challenges of adolescence, superhero responsibilities, and complex relationships, all while confronting new and familiar villains.