When Doctor Octopus (Earth-96283 - Rami) creates an inter-dimensional device, he soon forms an alliance with Spiderman villains from two other universes. Electro (Earth-120703 - TASM), Mysterio (Earth-199999 - MCU), Vulture (Earth-199999), Sandman (Earth-96283), Rhino (Earth-120703). The three Spider-Men from their respected Earths must team up to take on the newly formed SINISTER SIX.
Meanwhile, Villains across the Spiderverse are being pulled through the alternate earths, as well as other Spider People emerge.
[Features Suprise Cameo Appearances of actors Tobey Maguire, Andrew Garfield and Tom Holland, all playing themselves from the real world]
