While balancing life as a normal high-schooler in Queens, Spider-Man gets challenged by the Daily Bugle to catch an unknown threat, the Lizard. Peter wanting to focus on his high school life asks Liz to the homecoming dance with him. Meanwhile, Norman Osborn tasks famous hunter, Kraven to catch the Lizard and bring the lizard serum back to Oscorp. When Peter finds out that the Lizard was none-other than his science teacher, Dr. Connors and learns his plan of making his family, his next test subjects, Peter must save Connors from his addiction to the lizard serum and stop him from turning his family into lizards. But when Kraven captures the Lizard, Spider-Man must face off a duel between him and Kraven if Peter wants to save Dr. Connors...
