Taking place eight years into Peter Parker's career as Spider-Man, it focuses on the super-human crime lord Mister Negative, and his plot to seize control of New York City's criminal underworld. When he threatens to release a deadly virus with the assistance of a group of escaped supervillains known as the Sinister Six, Spider-Man must confront him and save the city while dealing with the personal problems of his civilian persona. He is accompanied in his efforts by former Daily Bugle colleague and ex-girlfriend Mary Jane Watson, New York City Police Department (NYPD) captain Yuri Watanabe, and Miles Morales, son of NYPD officer Jefferson Davis.
