Kingpin sends a broadcast framing Spider-Man for stealing a nuclear bomb that he secretly plans to detonate in twenty four hours. It can only be disabled by finding five keys that Spidey has to find whilst battling new supervillains that Kingpin has hired (The Lizard, Hobgoblin, Mysterio, and Electro). Meanwhile,a boy named Miles is bitten by a radioactive spider and gains spider-like abilities similar to Spider-Man, Spider-Man finds the keys, Kingpin has his wife Mary Jane Watson kidnapped, leaving the webslinger with not only the bomb to disarm but to save Mj, meanwhile,a boy named miles sneaks into the fight and returning to the station, Miles discovers a collider built by Kingpin, who hopes to access parallel universes to bring back his late wife and son, whose deaths he blames on Spider-Man. Miles watches as Spider-Man attempts to disable the collider while fighting Kingpin's enforcers, au Green Goblin and the Prowler. Spider-Man saves Miles, but au Green Goblin shoves Spider-Man into the collider, causing an explosion that severely wounds Spider-Man. Spider-Man gives Miles a USB flash drive designed to disable the collider, warning that the machine could destroy the city if reactivated. After watching in horror as Kingpin murders Spider-Man, Miles flees with Prowler in pursuit, eventually getting away as the city mourns about spider-man's death.
