After defeating The Lizard, Peter Parker is still living with Fred Meyers, and putting up with many different characters hood and bad, when two new enemies start causing many problems for the wall-crawler. Eddie Brock reappears out of the blue but with a new friend that he was injected with by Oscorp. He is waging a war on Oscorp, which has a lot going on with it too, Ned discovered the super soldier serum at Oscorp and accidentally became Hobgoblin, the Black Cat is still causing mischief, many different villains are after him, and he takes in a young protege named Miles Morales
