17 years have passed after the events of Spider-Man 3 (2007) as the movie takes place in 2022 after the events of J.C Chandor's Kraven The Hunter (2024) (Kraven movie took place in 2015), Daniel Espinosa's Morbius (2022) (Morbius movie took place in 2019/2020), Jon Watts' MCU Spider-Man: No Way Home (2021), and the mid-credits scene of Daniel Espinosa's Morbius (2022), Peter (Tobey Maguire) and Mary (Kirsten Dunst) are now ordinary people as they've become the parents of their daughter named, "Mayday Parker"... That is until a stranger was pulled out of his universe as he ended up in our beloved friendly neighborhood Spidey's universe as he would gather a sinister team to hunt him, and Peter has to stop them before it's too late.