The film, "Spider-Man 2099," is a high-octane, visually dazzling sci-fi thriller set in the year 2099 in Nueva York (a towering, neon-drenched Neo-New York). The world is ruled not by governments, but by mega-corporations, chiefly Alchemax. The protagonist is Miguel O'Hara, a brilliant but arrogant geneticist working for Alchemax who is trying to recreate the abilities of the legendary, long-dead Spider-Man to create corporate super-soldiers.
When Miguel tries to resign over ethical concerns regarding human testing, his corrupt boss, Tyler Stone, forcefully addicts him to a synthetic drug called Rapture, which bonds to the user's DNA. In a desperate attempt to purge the drug from his system using his own genetic equipment, Miguel is sabotaged by a jealous colleague, resulting in his DNA being spliced with 50% spider DNA.
The film is not a "friendly neighborhood" story. Miguel transforms into a frightening creature with talons, fangs, and red eyes. He doesn't have a spider-sense; he has enhanced vision and hearing. He becomes Spider-Man 2099 not to save the world, but initially to survive the "Public Eye" (Alchemax's private police force) and find a cure. However, seeing the rot of the city from the bottom up, he eventually accepts the mantle of the Spider to fight the corporate oppression he once served.
