In the year 2099, the young scientist Miguel O Hara is a scientist working for the company Alchemex creating a machine capable of imprinting genetic codes onto the human body, enabling their DNA to be quickty and easty modified. However, an experiment goes terribly wrong killing the human test subjects and Miguel tries to leave the project. The company leader, Tyler Stone, attempts to blackmail Miguel into staying on the project by addicting him to a company-controlled drug called Rapture which genetically modifies its consumers to become dependent on it. In an attempt to defy this blackmail, Miguel sneaks into his Laboratory at night and tries not to rewrite his own DNA to cure his addiction. Unfortunately, the machine was sabotaged by a jealous co-worker and half of Miguel's DNA is overwritten by spider genes, giving him spider powers. Miguel inspired by his idol, the late Peter Parker, uses these powers to become Spider-Man 2099, watching over the dark cyberpunk city of New York. In particular, Miguel attempts to bring down Tyler Stone and prevent him from using the genetic machine in inhuman experiments. The new Spider-Man soon finds challenged, not only by Stone and his new army of genetically modified corporate soldiers but also by an anarchist known only as the Goblin.
