Fan Casting

The government launches a nationwide crackdown on biotechnology, forcing Empire Biotech to close and leaving Peter Parker unemployed. As the government considers reopening select research facilities, Peter begins working at Horizon Labs, while mentoring young mutant Kitty Pryde and frequently helping Rio Morales at Feast. Meanwhile, Detective Jean DeWolff investigates Elias Wirtham, a former scientist transformed into the vigilante Cardiac after a biotech project caused the death of his son. Cardiac launches a targeted campaign against the government and those responsible, while radical terrorist Tarantula turns the protests into increasingly destructive attacks across New York. Peter becomes personally involved when Cardiac begins targeting Connors and others connected to his tragedy. Jean and Jefferson Davis pursue the case, with Jefferson skeptical of the investigation, while Daredevil enters the conflict when he discovers Richard Fisk helped fund the project that killed Elias's son. Cardiac ultimately decides his final protest will be undeniable: he uses stolen technology to transform Connors back into the Lizard, unleashing him on New York. Spider-Man battles the Lizard through the city, knowing that defeating him may mean losing Curtis forever. At the same time, Daredevil faces Tarantula in a final battle. Cardiac is arrested, but his actions succeed in making the government crackdown even worse. Peter defeats the Lizard, though Connors' fate remains uncertain. Peter goes back to the idea that keeping someone close means hurting them and ends things with M.J even though it breaks his heart. With biotech effectively dead, Peter remains at Horizon Labs, a creation of Oscorp, now seemingly run by CEO Max Modell whose medicine once helped keep Aunt May alive. Oscorp had to stay alive due to shareholders and the company's stock. The business returns to it's glory. An old enemy of Peter's has returned to society as the owner of Oscorp. Otto Octavius.