During a school field trip to Columbia University, Peter Parker, a shy nerdy high school outcast, has been bitten by a genetically enhanced spider. Peter discovers the spider has granted him superhuman abilities of a spider, he puts his powers to good use after his Uncle Ben is killed by a carjacker. Peter becomes the masked vigilante known as Spider-Man and he becomes the city's protector. However, Peter's life gets more complicated when he faces his arch-enemy, the Green Goblin who is actually Norman Osborn, the CEO of Oscorp and father of Harry Osborn. Green Goblin begins to terrorize the city that Spider-Man has sworn to protect. Peter's love for Mary Jane will ultimately get in the way of the Goblin's murderous goals