Peter Parker, a high school outcast, grapples with his feelings for Gwen Stacy and the mystery of his parents' disappearance. He discovers his father's old briefcase, leading him to Oscorp and Dr. Curt Connors, his father's former partner. After being bitten by a genetically modified spider, Peter gains superpowers and must confront Dr. Connors, who becomes the Lizard, while also learning to balance his newfound abilities with his personal life.
