After the defeat of the Sinister Seven, May Parker is finally a hero just like her father and is protecting the city of New York. However, while researching her father's old heroics, she sees that a different Spider-Man took the reigns from Ben Reilly after he initially retired. A man named... Miles Morales. She tries to find him to figure out what happened to him and why he quit being Spider-Man. When she finds him, it turns out, a couple years after May was born, he was fighting Chameleon and he figured out who he was and killed his parents. He was so distraught from the experience that he quit. After this revelation, a strange new being comes out of the woodwork named Toxin, a symbiote made from Venom and Carnage, who never really died. It bonds to Miles, and she has to stop him before he destroys New York.
