Decades after the original incidents, a high-tech facility in Singapore called "Ascension BioLabs" successfully crafts two new female hybrids using recovered alien DNA. Aurora (Eiza González) is the embodiment of primal, predatory instinct, while Maya (Hannah John-Kamen) displays an unexpected capacity for human empathy. After a violent breakout in Singapore, both creatures find their way to the urban labyrinth of New York City, where the fate of humanity rests on a collision course between biological evolution and artificial control.
In the heart of Manhattan, Maya forms a deep, dangerous bond with Elliot Reed (Finn Wolfhard), a student whose unique genetic mutation makes him the ultimate prize for the alien species. As Aurora begins a bloody campaign to propagate her kind and transform the city into a hive, Dr. Amara Navarro (Rosamund Pike) leads a ruthless team of hunters to reclaim her property. The film explores the thin line between monster and man, culminating in a subterranean war of ideologies where Maya must decide if she is the savior of humanity or the catalyst for its extinction.
