The Southern Book Club's Guide to Slaying Vampires is a 2020 horror novel by Grady Hendrix that blends supernatural thrills with social commentary on the lives of 1990s suburban housewives. The story follows Patricia Campbell, a bored housewife whose book club becomes her only joy, until a handsome new neighbor, James Harris, arrives and is suspected of being a vampire. The novel explores themes of sexism, classism, and the repression of women, all while delivering a suspenseful story with a satisfying, action-packed resolution.