The series, set in Toronto, Canada, serves as an alternate retelling of the original Scott Pilgrim graphic novel series and movie. Like in the original series, Scott Pilgrim, a bassist in an indie band, falls in love with Ramona Flowers, a mysterious delivery girl, attracting the attention of Ramona's seven evil exes. Things take an unexpected turn when Scott loses his battle against Ramona's first evil ex Matthew Patel and is seemingly killed. As the trajectory of everyone's lives, including those of Ramona's evil exes, change drastically as a result, Ramona learns that Scott may still be alive and investigates his disappearance.