"Give It Up, Turn It Loose" was the fourth single from American R&B/pop vocal group En Vogue's second album, Funky Divas (1992). The song's title is a reference to the 1969 James Brown song "Give It Up or Turnit a Loose". Released on November 12, 1992, the single reached number 15 on the US Billboard Hot 100, number 16 on the Billboard Hot R&B Singles chart, and number 22 on the UK Singles Chart. In 1994, it was nominated for a Grammy Award for Best R&B Performance by a Duo or Group with Vocals.[2] This song features Maxine Jones on lead entirely.