In an animated Marvel/DC crossover film, after escaping the Ravencroft Institute, the infamous gang of criminals known as the Sinister Six travel to Gotham City to perform a heist, which ends with them clashing with Task Force X, a government-sanctioned expendable black-ops unit, and end up getting captured and taken to Belle Reve. But when the Sinister Six reveal their true plan, to steal an extremely dangerous weapon from Belle Reve, the members of Task For X must ally themselves with Batman and Spider-Man to stop the Sinister Six from destroying New York City.