Mexican Gothic follows Noemí Taboada, a glamorous 1950s socialite, who travels to the remote Doyle mansion, High Place, to check on her cousin Catalina, who fears her husband and believes the house is haunted. Noemí discovers the Doyle family's sinister secrets, rooted in a history of eugenics and colonialism, and must confront the house itself, which seems to be alive and controlled by an ancient fungal entity.