The series is about an orphan boy named Eric (Nat Faxon), with his best friend Trevor (Charlie Day) and his two female friends, Vana (Lauren Lapkus) and Kitty (Melanie Lynskey), who are training to become sidekicks at the Academy for Aspiring Sidekicks. While dealing with intense sidekick training, Eric must also contend with the disappearance of his superhero mentor, Maxum Man (David Herman), and keep it a secret from the town of Splitsboro, his strict guardian Maxum Brain (Tom Kenny), his grumpy teacher, Professor Pamplemoose (Breckin Meyer) and the evil Master Xox (David Koechner).