The girls of Kappa Tau have left the hallowed halls of Wallace University behind in favor of another institution, this one with a medical bent. Having moved past the events at their sorority house, the remaining Chanels and Zayday have begun training to be physicians in a hospital recently acquired by Cathy Munsch, their former dean, where they are joined by Chad Radwell, and a couple handsome new faces -- secretive head surgeon Dr. Brock Holt and Dr. Cassidy Cascade, who suffers from a strange medical condition. As strange things start happening around the hospital, the former Wallace students reunite with intrepid investigator Denise Hemphill.
