A supermarket called Shopwell's is filled with anthropomorphic grocery items that believe that the human shoppers are gods, who take groceries they have purchased to a utopia known as the Great Beyond. Among the groceries in the store is a sausage named Frank, who dreams of living in the Great Beyond with his hot dog bun girlfriend Brenda and of finally consummating their relationship. Frank and Brenda's packages are chosen by a woman named Camille Toh to leave Shopwell's. A returned jar of Bickle's Honey Mustard tries to warn the groceries that the Great Beyond is a lie; nobody listens except for Frank. Honey Mustard tells Frank to seek out a bottle of liquor named Firewater, and then commits suicide by falling on the store floor. This creates an accidental cart collision that causes Frank, Brenda and several groceries to fall out of the cart, including an aggressive douche whose nozzle is bent on impact. Douche swears revenge against Frank and Brenda. Seeking to verify Honey Mustard's warning, Frank leads Brenda to the store's liquor aisle. There, as he smokes marijuana from a kazoo pipe, he learns from Firewater that he and other non-perishable foods invented the story of the Great Beyond as a noble lie to assuage past foods' fears of being eaten by shoppers. Frank, vowing to reveal the truth to the groceries, is encouraged to travel beyond the store's freezer section to find proof. Meanwhile, Frank's friends Carl and Barry are horrified as they witness the brutal murder of other purchased foods being cooked and eaten by Camille. Carl is sliced in half, but Barry escapes the house and encounters a human drug addict, who injects himself with bath salts and becomes able to communicate with his groceries. While attempting to cook Barry, the addict is decapitated in a freak domestic accident. After Frank separates from his friends, who disapprove of his skepticism of the Great Beyond, he discovers a cookbook behind the freezer section and reveals its contents to the rest of Shopwell's groceries. Initially panicking, the groceries choose not to believe Frank out of fear of losing their sense of purpose. Barry and the groceries from the addict's home return to the store with his severed head, proving that the humans are not gods, but are mortal. The groceries drug the human shoppers and employees using toothpicks laced with bath salts, and several humans are gruesomely killed in the ensuing battle. Douche takes control of Darren, the store manager, by inserting himself into his anus and yanking on his scrotum to puppeteer his actions, but Barry and the other foods defeat them with an improvised rocket. The groceries celebrate their victory with a store-wide orgy. Afterwards, the gang meets Firewater and Gum, a Stephen Hawking-esque wad of chewing gum. They have had a psychedelic experience and discovered that their world is not real, and they are merely cartoons voiced by famous actors in another dimension. Gum has constructed a portal to this dimension, and the groceries decide to travel there to meet their creators.
