Peter Parker's world is crumbling: Mary Jane has left him, and the winged Vulture transforms a tired worker into the living lightning bolt Electro during a heist. As Spider-Man battles these threats, he finds an unlikely ally in the seductive Black Cat, secretly his new editor Felicia Hardy, whose betrayal reveals a deeper conspiracy. Meanwhile, Dr. Curt Connors' desperate experiments turn him into the Lizard, forcing Peter to confront a mentor become monster. With Aunt May's life in the balance and a new menace discovering the Goblin's abandoned lair, Peter must choose whether the mask is a burden or a duty—before the city pays the price.