Five years after the events of Saints Row 2, the 3rd Street Saints have merged with the Ultor Corporation to become a media and consumer empire, with assets that include an energy drink, a lifestyle brand, and a chain of clothing stores. While robbing a bank to promote the upcoming Saints Row: The Movie, the Boss and top lieutenants Shaundi and Johnny Gat experience unanticipated resistance from the staff and are arrested by corrupt policemen. They are turned over to Phillipe Loren, the mastermind behind an international criminal enterprise known as the "Syndicate" who wishes to make a deal with the Saints, seeing them as a threat. The Saints refuse and stage a breakout, with Gat seemingly sacrificing himself to allow Shaundi and the Boss to escape.
